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[PubMed] [Google Scholar] 87.Gotthardt M, Bh MP, Grass J, et al

For example, it has been reported that CD8 + T cells have facilitated tumor ferroptosis by releasing IFN-, which disrupts the cystine uptake by tumor cells, triggers lipid peroxidation accumulation, and ultimately results in ferroptotic tumor cell death ( + T cells are more sensitive to ferroptosis inducers RSL3 than B16 and MC38 cancer cells ( + T cells underwent lipid peroxidation in lipid laden TME and became dysfunctional (179), targeting lipid peroxidation to enhance cancer therapy must consider the complex nature of TME

Ilyas, S

Alle zur Zeit bestehenden klassischen Therapien sttzen entweder das Phnomen der Oxidation, also die oxidative Seite lebender Systeme, oder greifen durch Arzneimittel, die als Xenobiotika zu ihrem Abbau und zur Metabolitbildung der Oxidation bedrfen, in die "Oxidative Potenz" des Stoffwechsels ein wie Cytochrom-p-450-System und Arzneimittelabbau.All currently existing classic therapies either support the phenomenon of oxidation, ie the oxidative side of living systems, or intervene in the "oxidative potency" of the metabolism like cytochrome by drugs that need xenobiotics to break them down and to produce metabolites