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Description
Redoxosomes contain redox proteins that are involved in transmitting ROS signals from interior to outer membranes, and they regulate ROS as a secondary messenger (Oakley et al., 2009)
Using human liver microsomes, it was also recently reported that sulforaphane metabolites (0-200 M) had little-to-no effect on the activities of CYP1A2, CYP2B6, CYP2D6, and CYP3A4 (23)
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These findings collectively suggest a plausible mechanism whereby GSDMD-N could be transferred indirectlypotentially via extracellular vesiclesfrom supporting cells to hair cell membrane and directly inducing pyroptosis
