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In vivo delivery of labeled 68 Ga-EPI@gVLPs demonstrated that the median survival rate was increased to more than 50 days when mice received 2 injections (once a week) compared to the control group (median survival: 26 days) (Fig

In a breast cancer xenograft model (MDA-MB-231), mitochondria-targeted nanomedicines co-assembled from berberine and doxorubicin effectively repairs mitochondrial protein defects (Mfn1/Drp1) and inhibits the activity of MMP-2 and MMP-9, resulting in significant suppression of tumor cell proliferation and lung metastasis [242]

PMID: 28885712

Mutations blocking phosphorylation significantly enhance SOS1 binding