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While neonatal HIBD has been shown to activate endogenous brain neurogenesis, spontaneous endogenous brain neurogenesis is limited and insufficient to fully compensate for neurons lost to injury ( Figure 1 Overview of endogenous neurogenesis Over recent years, our understanding of spontaneous endogenous neurogenesis shifted from its existence exclusively during embryonic and prenatal mammalian development ( NSCs differentiation depends mainly on the components of their microenvironment, including neuronal cells, stromal cells, and the extracellular matrix