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[11] observed that NNMT knockdown increased both NAD + levels and oxygen consumption in WAT
It is a substrate: cells need it to run the electron transport chain, generate ATP, and activate a class of repair enzymes called sirtuins and PARPs
Smart, et al., 2000) (Figure 2)
Phosphorylation is connected to oxidation via microtubule associated protein kinase pathway and through activation of the transcription factor nuclear factor-B, thus potentially linking oxidation to the hyperphosphorylation of tau () proteins [35]
