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59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility

29 GaoC.CatucciG.CastrignanoS.GilardiG.SadeghiS

SummaryDisease Initiation and the Metabolic Approach It is becoming apparent that the pathogenesis of conditions like neurodegeneration, insulin resistance, endocrine imbalances, liver and kidney disease are linked to metabolic disorders and in particular to mitochondrial dysfunction

465 The anterior cingulate cortex, essential for emotional pain processing, shows increased blood flow in patients with PDPN, a hyperperfusion state that normalizes following duloxetine treatment