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Description
When it reaches the mitochondria inside a target cell, it disrupts the very structures that prohibitin normally protects
Safety was characterized over weeks to a few months in metabolically healthy-to-obese adults
Because TAM was administered systemically, this delayed weight gain in female mice could be because of TAM effects on multiple central or peripheral tissues
NNMT inhibition or NNMT knockdown improves insulin sensitivity and normalizes glucose tolerance and fasting blood glucose levels [14], but the mechanisms by which NNMT regulates insulin sensitivity and blood glucose homeostasis are unclear
