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[1] [4] The safety of glutathione injection in patients with severe hepatic or renal impairment has not been established, and its use in these populations should be carefully considered and monitored by a healthcare provider
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Constitutively activated -catenin signaling, due to APC deficiency or -catenin mutations that prevent its degradation, leads to excessive stem cell renewal/proliferation that predisposes cells to tumorigenesis
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