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These processes do not only depend on intracellular dynamics of hepatocytes, but are in part regulated by intercellular signaling between hepatocytes and immune cells such as the livers resident Kupffer cells (KCs) and recruited monocyte-derived macrophages (ms) 14

Another indirect effect appeared when breast cancer cells were co-cultured with fibroblasts, believed to play an important role in promoting the growth of breast cancer cells

Dephosphorylation and activation of MTHFR may also serve as a cellular response to hyperhomocysteinemia (HHcy), ensuring sufficient concentrations of active folate for the remethylation of Hcy and the elimination of toxic effects caused by this amino acid [23]

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