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Combination protocols address two sequential bottlenecksfat mobilisation and fat oxidationthat single-agent therapies rarely optimise simultaneously, producing 2835% greater adipose reduction in research models

The crystal structure of human GPx3 revealed that each subunit contained a selenocysteine (Sec) residue and the active Sec-53 was located in a pocket on the protein surface with Gln-87, Trp-161 and Asn-162 nearby 13 , which formed a catalytic tetrad highly conserved in the selenium-dependent GPx family 14