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Continued progress will depend on technologies such as single-cell multi-omics, spatial proteogenomics, intravital imaging of iron flux, and ferroptosis-reporter mouse models, which can resolve these interactions with high precision

Notably, these genetic foci are strongly correlated with one or more other immune-mediated disorders, such as ankylosing spondylitis, CD, and psoriasis 41 , indicating that PSC is positioned as an immune-mediated or autoimmune disease

Cardiovascular disease Some healthcare professionals propose chelation therapy as a treatment for cardiovascular disease

Men may notice lower libido, erectile dysfunction, or partners report declines in semen parameters on testing, such as lower concentration or reduced motility