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2024;12:e18626
Taken together, as shown also in Figure 2, compared with that (3.278 10 6 M) of native semaglutide (PDB entry 4ZGM [24]), semaglutide mutant 524 possesses a significantly higher (at least one degree of order) GLP-1R ECD binding affinity (1.462 10 7 M) to enhance GLP-1R activation
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