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In certain regions of the world, marginal or subclinical vitamin B 12 deficiency may be fairly common in other age groups as well, including children, premenopausal women, and pregnant women, primarily due to low intake of animal-source foods (reviewed in 5)

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Proper reconstitution technique requires injecting bacteriostatic water slowly down the vial wall, allowing passive dissolution for 510 minutes, and never shaking the solution

Some of these issues could be alleviated with robust human-based research, followed by FDA approval if warranted