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The tissue microenvironment regulates the differentiation of precursor monocytes into macrophages
In SCA3, ASOs have been used either to decrease overall ATXN3 levels or to generate a truncated ATXN3 which lacks the polyQ expansion [280, 281]
Treated aged mice showed restored fur density, improved kidney function, increased fitness, and reduced senescence markers
352,435,485 Metabolic disease also reduces sex hormone-binding globulin (SHBG) production due to liver dysfunction and increased inflammatory cytokines
