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Avoid alcohol and medicines that interfere with DAO

Besides ROS homeostasis, healthy mitochondrial function is also maintained by the coordinated activities of mitochondrial biogenesis, dynamics, and mitophagy, also known as Mitochondrial Quality Control (MQC)

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

Analysis of clinical data clearly demonstrates that mitochondrial dysfunction accompanies disease progression in a substantial proportion of patients