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Nevertheless, prolonged cortisol elevation can impair these defenses, developing ng a vicious cycle, typically evident in PTSD

Reperfusion exacerbates this process by infusing oxygen, which causes a burst of ROS and exacerbates oxidative stress

Moreover, study showed a positive correlation of persistent fatigued symptoms with IL-2 production and negative correlation with IFN-/IL-2 ration in case of Q fever infections (bacterial infections causing flu-like symptoms) (Keijmel et al