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For example, mitochondrial dynamin-like GTPase (OPA1), which regulates mitochondrial morphogenesis, fusion, and energy dynamics, can modulate cellular sensitivity to ferroptosis by regulating mtROS and integrating the cellular stress response [189]

Emodin synergistically enhanced the antiproliferative effects of paclitaxel in NSCLC (A549) cells, augmenting apoptosis through up-regulating the protein expression of Bax, Bcl-2, as well as activating the phosphorylation of AKT, and ERK, as well as activating Caspase-3

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