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However, it should be noted that TE may have limitations in distinguishing between early fibrosis stages (F0-F1), which could influence the sensitivity of the method in some cases [54]

Ferroptosis-related genes that are transcriptionally regulated by Nrf2 have been reported, these include genes for GSH regulation (synthesis, cysteine supply via SLC7A11, GSH reductase, GPX4), NADPH regeneration which is critical for GPX4 activity [glucose-6-phosphate dehydrogenase (G6PD), phosphogluconate dehydrogenase, malic enzyme], and iron regulation (including iron export and storage, heme synthesis, and catabolism) (Kerins and Ooi, 2018)

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She was predeceased by her Uncle Shane Gascon