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The main adverse events reported by male AAS users to SERMs (clomiphene and tamoxifen) were decreased libido and erectile dysfunction (24%), acne (21%), fatigue (19%), mood disorders (13%), visual disturbances (5%), arthralgia (4%), insomnia (4%), and hot flushes (2%)

High-molecular weight HA can inhibit this inflammatory response to a certain extent by inhibiting the effects of the low-molecular weight form (71) through competition for receptors or interference with the associated signal transduction pathway (72)