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Description
These data suggest that arrestin-3 recruitment improves the therapeutic utility for opioids by reducing analgesic tolerance so that dosage may remain low enough to mitigate respiratory risks

Studies have shown that metformin is correlated with TCA cycle, lipid metabolism, glucose metabolism, although the results were inconsistent between studies and not enough to derive robust conclusions

C.ShimauchiT.LemayS

Toxicology 227 , 94104 (2006)
