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However, the interaction between the carnitine pool and the endocrine system is complex, and more studies are needed to understand the specific mechanisms involved

Trials should also incorporate sex-specific analyses, age related stratification, and clinically relevant comorbidities such as gastrointestinal dysfunction and sleep problems, all of which can modulate treatment efficacy

Rare mutations in the SLC22A5 gene can cause a genetic condition called primary carnitine deficiency, which is usually discovered in infancy because it affects brain function, muscle function, and blood glucose levels

Whether parallel alteration in platelet responsiveness and long-term thrombosis risk occurs in subjects remains to be determined, but as noted above, elevated serum levels of carnitine are associated with enhanced risks of major adverse cardiovascular events (6)