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4(4): p.193-202

Activation of XKR8 by caspase-3 triggers NET formation The signaling cascades that orchestrate NET formation are extremely intricate and not yet fully understood 15,26

7 Dysregulation typically results from mutations in pathway components or altered expression of Wnt ligands and receptors

These effects are mostly due to compounds that cause induction or inhibition of the enzymes responsible for oxidative metabolism belonging to the cytochrome P450 (CYP) family, the main system used to eliminate drugs from the body [48]-[50]
