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Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2
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Furthermore, microsomal PGE synthase 1 (mPGES1) and PGIS are coupled with COX2 at the perinuclear membrane, and preferentially produce PGE 2 and PGI 2 during the later phase of the LPS-induced response (324 hours of stimulation) 36,37
