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The reaction catalyzed by -ECS/GSH1 is considered the rate-controlling step of GSH synthesis, and the activity of this enzyme is regulated by cellular levels of cysteine and glutamic acid, and feedback inhibition by -EC and GSH (Hernndez et al., 2015

2.4 Establishing protein-protein interaction (PPI) network The target obtained from SJZD-PD was imported into the String database ( (Szklarczyk et al., 2015)

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