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One interesting example is Pro 1150 located close to the beginning of CL7, which connects TM15 to TM16 (53)

This can lead to a buildup of fat in the liver

His physical examination reveals pallor, alopecia, and gum ulcerations alongside a central venous catheter without surrounding erythema

Prolonged angiogenic signaling may encourage unwanted vascular growth in tissues where balance is key (think: cancer cells use these same pathways to grow we want to avoid that) , especially if theres a history of cellular overgrowth or injury-prone tissue
