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Sustained ion release activates the eNOS/NO signaling pathway, significantly upregulating expression of angiogenic factors (VEGF, b-FGF, and TGF-), as shown in Figure 5G
doi: 10.1073/pnas.1605635113 53 KandimallaRReddyPH
We posit that antioxidant functions of parkin may explain many of its previously described, protective effects in vertebrates and invertebrates that are unrelated to E3 ligase activity
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