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Importantly, even in the absence of overt clinical manifestations, CAA may elicit localized inflammatory responses, potentially mediated by the recruitment of monocytes and macrophages (Yamada, 2000)

Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine

The effects depend on the peptide type, dose, and individual health
