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Based on the findings of this study and in accordance with the recommended methods outlined in the C28-A3 and WS/T 402-2024 guidelines, we established gender-specific reference intervals for serum GR activity in apparently healthy adults in eastern China: 26.651.8 U/l for males and 29.755.3 U/l for females

While the C-terminal unit (C0362) is secreted and functions as a cysteine protease that disarms the complement system via degrading key complement factors such as C3 and C4, the N-terminal functional unit (N0362) with two Big domains binds to FPR1 and CXCR1/2 receptors with high affinity and blocks neutrophil chemotaxis and activation most likely through competition inhibition, thereby annihilating both the complement system and neutrophils and rendering bacteria protection from these two innate defense mechanisms

Inflammatory diseases, including multiple sclerosis (MS) and meningitis, are characterized by inflammation and damage to the nervous system (11)

It functions as a potent antioxidant by neutralizing free radicals and reducing oxidative stress within cells