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The NHS advises that taking up to 2mg (2000 micrograms) daily of vitamin B12 supplements is unlikely to cause harm, with no established upper limit in the UK

There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care

Some publish lengthy local coverage determinations (LCDs) specifying how many injectable services they will cover

Women who are pregnant need to be particularly vigilant to avoid any deficiency in B12 as babies who are born with a deficiency in vitamin B12 levels are susceptible to experience severe neurological issues