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The 3-ketosphinganine reductase (3KR) enzyme is encoded by the KDSR gene
5.3 PKC and blood-retinal barrier dysfunction in diabetic retina PKC has been implicated in blood-retinal barrier (BRB) dysfunction in diabetic eye disease

These enzymes are the carnitine acetyltransferase and the carnitine octanoyltransferase

The drug can also suppress appetite and lead to weight loss, another effect that some users find desirable