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In addition, endothelial cells are involved in angiogenesis and mediate crosstalk between fibroblasts and various immune cells, and this crosstalk modulates fibroblast responses and the inflammatory and reparative microenvironment [163]

The intestinal mucosal epithelium consists of a single layer of columnar epithelial cells, including absorptive enterocytes responsible for nutrient uptake, goblet cells that secrete the gel-forming glycoprotein mucin 2 (MUC2) as the primary constituent of the mucus layer, and Paneth cells residing in the crypt bases which secrete antimicrobial peptides (e.g., defensins, cryptdins) and lysozyme contributing to innate immune defense, and enteroendocrine cells that release hormones regulating intestinal function [10]