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For example, the ionizable lipid material DAL4-LNP containing diaminic groups of different head groups (DAL) can efficiently deliver different mRNAs to tumor cells, and intratumoral injection of DAL-LNPs loaded with IL-12 and IL-27 mRNA can induce CD8 + T cell infiltration into tumors and significantly inhibit tumor growth compared to IL-27 and GM-CSF mRNA monotherapy (145)

A.EllisJ.OgilvieR.MalmivaaraA.van TulderM

Derivatives thereof from animals A61K38/018Hydrolysed proteins

In a few cases, a cysteine S -conjugate sulfoxide has been shown to be a substrate of purified cysteine S -conjugate -lyases yielding pyruvate and ammonium ion (Larsen and Stevens, 1986, Tomisawa et al., 1986)