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The first records of its use date back to ancient Sri Lanka, where even today it is an important component of Ayurvedic medicine
Thus, excess GPx1 was found to attenuate hydrogen peroxide-mediated vasodilation responses [74] and attenuate ROS-mediated signaling to affect insulin sensitivity and promote type 2 diabetes in a mouse model system [100]
This risk is significantly elevated in immunocompromised individuals or those with specific comorbid conditions
