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Description
Induction of necrotic cell death and activation of STING in the tumor microenvironment via cationic silica nanoparticles leading to enhanced antitumor immunity
340 In humans, there are three types of Hedgehog ligands: Sonic Hedgehog (Shh), Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh), which are disparate in the timing of expression, spatial distribution and action characteristics
According to Schafer and Buettner (2001), the ratio of GSH to GSSG reveals the redox status of cell (Schafer and Buettner, 2001) Therefore, the reduced levels of GSH peroxidase and GSH-S-transferase determine the defense mechanism against ROS ( Because of its capacity to convert extremely reactive superoxide radicals into hydrogen peroxide (H2O2) and oxygen, SOD is thought to be the first line of defense against ROS (Marwicka and Ziba, 2021)
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