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PARP inhibitors (olaparib, niraparib, rucaparib) have revolutionised maintenance therapy for BRCA-mutated ovarian cancer while exhibiting minimal off-target toxicity toward dormant follicles [135,136,137,138], whose low replicative rate renders them less dependent on poly-ADP-ribose-polymerase activity [139]

This is a much bigger problem, Rasmussen said

Specifically, for patients with head and neck cancerswho frequently undergo radiation therapy as a part of their treatment regimenthe risk of inadvertent brain exposure to radiation and subsequent ferroptosis-induced brain injury is a significant concern

The compound has a half-life of approximately six days, which allows for convenient once-weekly dosing