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Description
The intestinal barrier is a living interface composed of: A single layer of epithelial cells Tight junction proteins regulating passage between cells A protective mucus layer A diverse microbial ecosystem supporting mucosal integrity When functioning correctly, this system allows nutrients to be absorbed while preventing bacteria, toxins, and inflammatory molecules from entering circulation

doi: 10.1007/s00401-009-0591-3

Obesity is a disorder of energy balance

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