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2.6 Histology and immunohistochemistry of PDX models For histopathological analysis, 5 m sections of formalin fixed paraffin embedded (FFPE) tumor samples were deparaffinized in ROTICLEAR (Carl Roth GmbH, Karlsruhe, Germany) and rehydrated using ethanol and distilled water
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Manufactured in Scotts Valley, CA, under the Good Manufacturing Practices (cGMPs) established by the US Food and Drug Administration (FDA).
Matrix metalloproteinases (MMPs), particularly MMP-1 and MMP-2, actively break down existing collagen
