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Invest 131 (5), e140695

Unfortunately, MTX can trigger apoptosis in healthy tissues, including the liver (Abbas et al., 2023b)

This argument is plausible it reflects a well-documented problem in drug development where unpatentable compounds struggle to attract industry funding regardless of their scientific merit but it should be noted that this explanation, while widely discussed, has not been formally established in the published literature as the primary reason for the evidence gap

In this sense, it appears that the delicate equilibrium in redox biology might dictate the shift towards physiological or pathological conditions