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Imbalanced mitochondrial Ca 2+ homeostasis not only exacerbates oxidative stress but also activates the unfolded protein response and pro-inflammatory signaling cascades, establishing a self-amplifying neurodegenerative loop 31

Second, innovative nanoformulation strategiessuch as ligand-functionalized, stimuli-responsive, or biodegradable carrierscan improve targeted delivery, controlled release, and minimize off-target effects (Singh et al., 2025)

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With regard to degradation, GSH is degraded in an extracellular manner followed by GSH export and is hydrolyzed by GGT/gamma-glutamyltranspetidase