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Prostaglandin-E2 is produced by adult human epidermal melanocytes in response to UVB in a melanogenesis-independent manner

The resulting acetoxyarylamines are highly unstable, spontaneously forming arylnitrenium ions that bind to DNA (Bland & Kadlubar, 1985) and ultimately lead to mutagenesis and carcinogenesis (Kerdar et al., 1993)

FF (500 L) was mixed with methanol-acetonitrile (400 L, v/v = 2:1, with formic acid and succinic acid-2,2,3,3-d4), and KGN cells (110 7 ) were treated with methanol-water (v/v = 3:1, with 0.1% formic acid and succinic acid-2,2,3,3-d4), respectively