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In another study using HT22 cells, huperzine A (HupA) + wortmannin treatment stopped the downregulation of p-mTOR, p-Akt, and p-p70s6 kinase under oxidative glutamate toxicity, leading to the conclusion that HupA abrogates oxidative glutamate toxicity in mouse hippocampal cells via the activation of the BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway 51

Research indicates that breast milk contains varying levels of glutathione, which plays a crucial role in providing antioxidant support to infants

Therefore, based on summaries of the research regarding the relationship between breast cancer and GPxs, this article focused on the molecular mechanism and function of different GPxs and their diverse roles in the occurrence and development of breast cancer, further clarifying the pathogenesis of breast cancer and providing a potential direction for further studies on the treatment of breast cancers
