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Disorders of mitochondrial import, export and translation, including sideroblastic anemia with ataxia, EVEN-PLUS syndrome and mitochondrial complex I deficiency due to nucleotide-binding protein-like protein gene defect, have also been implicated in ISC biogenesis defects

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The study used various methods, including lipidomics and RNA sequencing, to demonstrate that CBD modulates fatty acid metabolism, enhancing ISCs proliferation