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Accumulation of Pael-R causing ER stress could be relevant to the pathological mechanisms that underlie autosomal recessive PD
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Failure to provide blood, and keep the haemoglobin level to an acceptable minimum level, which is over 9g/dl in TDT patients, also causes the body to keep producing empty red cells, by expanding the activity of the bone marrow, both within the bone marrow cavity and in other parts of the body, such as the liver, the spleen and the lymphatic system
Noda S, Tanabe S, Suzuki T
