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CB-839 was kindly provided by Calithera Biosciences (San Francisco, CA)

Camenga D , Gutierrez KM, Kong G, Cavallo D, Simon P, Krishnan-Sarin S

: Vitamin B12 administered 1mg/week intravenously for 3 months : IV supplementation with folinic acid 3mg plus B12 1mg intravenously for 3 months/week : Initially received cobalamin 1250 g per week for 2 months, orally, then received 15 mg folic acid daily for 8 weeks, orally