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Red blood cells can be harmed by a relatively high dosage (600-800g) taken all at once or spaced out over a few days

10.1021/acs.jafc.6b03861 6 BaoJ.WangJ.ZhangX.-Y.NongX.-H.QiS.-H

9 This is the first human study to demonstrate that a single dose of NR can cross into the brain and directly raise cerebral NAD+ levels, providing evidence that NR boosts NAD+ where it matters mostat the cellular level in the brain

This action further attenuates IMQ-induced skin inflammation in rodent models (79)
