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These studies revealed that DSePA was not an efficient GPx mimic and its ability to catalyze the detoxification of hydroperoxides through the GPx cycle was considerably lower than ebselen [82, 83]

GSH (100 gmL 1 ) was incubated at 37 C with the above conditions for 24 h or until at least 20% of peptide was degraded

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Furthermore, the decreasing number of low molecular weight drugs being approved for clinical use has increased the efforts to develop peptides as potential successful therapeutics [2]