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Interestingly, some ligands have a bimodal effect, activating the channel in low concentrations while inhibiting it at higher doses, as it is the case of nicotine and menthol (Karashima et al., 2009

H.Shin OgawaL.ChimmanamadaD.InoueT.ChuJ.et al (2012)

It is not for human or veterinary consumption, diagnostic, or therapeutic use

Vanbrabant et al
