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Description
The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

Tirzepatide escalation takes 20-24 weeks

Energy improvements typically appear within 1 to 2 weeks
Adverse reactions to diuretics
