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The combination of the amylin analogue pramlintide and the recombinant human leptin metreleptin caused significant weight reductions ( - 11.5kg) in comparison with monotherapy in a 24-week phase 2 clinical trial [248]

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Tirzepatide escalation takes 20-24 weeks

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Energy improvements typically appear within 1 to 2 weeks

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Adverse reactions to diuretics

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