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MOTS-c has a short half-life (46 hours) and works best when AMPK is already primed by low ATP (fasted state, pre-training)

For broader context, research discussions around cortisol and GLP-1 may help explain why stress biology, appetite signaling, and metabolic regulation often overlap during menopause

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This strain-specific efficacy correlates with BAA-835's 125 unique genes, which encode critical regulators of Treg differentiation, SCFA biosynthesis, and GPR43 signalingfunctional modules absent or impaired in strain 139's 278 unique gene repertoires