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doi: 10.1038/s41586-020-1953-1

Administering folic acid and vitamin B12 significantly delayed disease onset and extended the lifespan of ALS mouse models by lowering plasma HCY levels, preventing microglia and astrocyte activation, and inhibiting the expression of inducible nitric oxide synthase and TNF- [323] (Figure 5)

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Effect of long-term valproic acid administration on the efficiency of carnitine reabsorption in humans
